The study investigated depression, emotional intelligence domains (self-awareness, relationship management, self-management and social awareness) self-esteem, and drug use as predictors of suicide ideation (S.I.) among students in federal universities in Owerri, Imo State. A sample of students identified as suicide ideators were drawn from selected departments in the schools using multistage simple random sampling and non-proportionate sampling technique. The study adopted the correlational research design. Six research questions and six corresponding hypotheses guided the study. Beck Depression Inventory (BDI-2), Emotional Intelligence Questionnaire (EIQ) Drug Use Scale (DUS), Rosenberg Self-Esteem Scale (RES) and Suicide Ideation Scale (SIS) were used as instruments for data collection. Validity of the instruments was done by experts’ opinion while reliability index of 0.76, 0.67, 0.82, 0.82, 0.77, 0.95, 0.78, 0.81 were realized for depression, emotional intelligence domains, drug use, self-esteem and suicide ideation respectively using Cronbach Alpha method. Multiple as well as simple linear regression were used to analyze the data generated. Specifically, the associated ANOVA were used to test the tenability of the null hypotheses at 0.05 alpha level. Findings were that self-esteem independently does significantly predict suicide ideation. Drug use and depression independently do significantly predict students suicide ideation. Emotional intelligence domain of self-management does not significantly predict suicide ideation, whereas the domains of self-awareness, relationship management, and social awareness, independently, do significantly predict students suicide ideation among students in federal universities in Owerri, Imo State. Jointly, the domains of emotional intelligence had a prediction of suicide ideation. Drug use independently predicted suicide ideation among the students and also when taken jointly with emotional intelligence and others. Based on these, recommendations were that factors that cause depression among the students should be properly addressed. All factors that engender drug use among the students should be proscribed, and there should be an avoidance of conditions that subject the students to difficulties capable of resulting in low self-esteem and invariably depression and drug use. Other recommendations made included that disruption in academic calendar, and unconducive learning environments, should be taken care of. The use of drugs by the students should be looked into by carrying out more awareness campaigns on the effect of drug use as well as encouraging the positioning of counselors strategically in a way that the students can easily get correct counsels in any given pressing situation they encounter